Cleanshield becomes more effective to its full functionality when you take it on an empty STOMACH as I always advice my customers. What I mean by this is in the morning, when you wake up and you have not eaten or drink anything or even not Brush your teeth, this is best time to take your first dosage. And After taking on an empty stomach, Wait for it to stay on your stomach for at least 30 minutes or more, drink enough water immediately after 30 minutes if you can. After drinking the water you can wait for another 30 minutes to add to one hour before you eat NORMAL FOOD. This Applies to MORNING, AFTERNOON, AND EVENING DOSAGE